Informatics Publishing Limited

Mukesh K. Nagar ¹, P. N. Dhabale ¹, A. H. Hosmani ¹

Affiliations
1 Govt. College of Pharmacy, Karad, Dist: Satara, Maharashtra- 415124, IN

Abstract

The present study describes a simple, accurate, precise and highly sensitive UV-spectrophotometer method for the determination of Telmisartan in pharmaceutical dosage forms. Telmisartan is used for the treatment of hypertension. Absorption maxima of Telmisartan in methanol were found to be at 297nm. Developed method obeyed the Beer's law in the concentration range of 2-22 μg/ml and regression coefficient was found 0.9999. The results of the tablet analysis were validated with respect to accuracy (recovery), linearity, limit of detection and limit of quantitation were found to be satisfactory.

Keywords

Spectrophotometry, Telmisartan, Validation, Accuracy.

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Mukesh K. Nagar ¹, Karishma R. Waghmare ¹, P. N. Dhabale ¹, Pradeep D. Chanekar ¹, Suresh Bhatia ¹

Affiliations
1 Govt. College of Pharmacy, Karad, Dist: Satara, Maharashtra- 415124, IN

Abstract

A simple, clean, fast, efficient and economical, microwave-assisted method for the synthesis of Phenytoin has been developed. The antiepileptic drug Phenytoin is synthesized by reaction between Benzil and Urea. The activation of Benzil and Urea is a type of pinacole-pinacolone rearrangement reaction. Comparison of microwave assisted synthesis with the conventional methods of synthesis demonstrates advantages related to shorter reaction time and in some cases better reaction yields. Moreover, microwave activation is a very convenient method for the synthesis of phenytoin resulting in good yield and purity.

Keywords

Phenytoin, Microwave, Conventional, Benzil, Synthesis.

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